Effects of caloric restriction on the antagonistic and integrative hallmarks of aging

Aging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes 'healthy brain aging' very important. Studies suggest that caloric restriction (CR) non-genetic intervention reliably extends life- and healthspan. Here, we review the CR literature related to both subject of aging alterations in cell cycle machinery, especially surrounding regulation E2F/DP1 complex, elucidate cellular protection mechanisms induced via dietary applications. The extending lifespan appear exert their effects by promoting survival individual cells, downregulating proliferation, inducing stem quiescence, results keeping reserve extreme needs. This instinct cells believed cause some molecular adaptations maintenance system. Avoiding energy waste proliferation machinery long term this due limited nutrient supply environment. Such protective mechanism diet could be promoted downregulation crucial cycle-related transcription activators. article aims bring attention importance promote healthy aging. It will provide insights into alternative targets new treatments or neuroprotective approaches against pathophysiologies.